School Of Science And HealthMolecular Biology of the Immune SystemWestern Sydney University Unit Code: 300757.2
Discipline: MEDICAL SCIENCE
Student Contribution Band: 3
Level: 3
Credit Points: 10
Assumed Knowledge
A sound knowledge of cell structure, protein structure, gene expression, protein synthesis, protein secretion and protein degradation. Some understanding of cell signalling pathways would be an advantage.
Equivalent Units
300552 - Molecular Biology of the Immune System
Incompatible Units
300223 - Cell Signalling and Molecular Immunology, J3830 - Immunology and Cell Signalling, 300229 - Immunology
Prerequisite
300219 Biochemistry 1 OR 300555 Proteins and Genes
About this Unit
The immune system relies on a complex interplay between cells, receptors and signalling molecules for its effective operation. Antibody- and cell-mediated immune responses will be examined from a molecular and biochemical perspective. Topics include B- and T-cell receptor gene expression, antibody structure, function, maturation; MHC genes and proteins; differentiation and activation of B and T cells; antigen processing and presentation; the roles of cytokines. The relevance of this knowledge for understanding disorders of the immune system will be emphasised throughout. Medical and diagnostic applications of hybridoma technology, antibody engineering and advances in vaccine development will be discussed. The laboratory course will develop technical and interpretative skills in relevant techniques.